Clinical trials are conducted in a healthcare setting (hospital or clinic) and are monitored by a trained healthcare professional. An Institutional Review Board (IRB) is a committee made up of doctors, ethicists, members of the general public, and administrators that approves andmonitors all clinical trials. This group is held responsible for agreeing that a trial does not represent an unreasonable risk to patients who are participating. Trials are also reviewed by the U.S. Food and Drug Administration (FDA). Your doctor is responsible for your well-being and is the best person to decide whether or not a clinical trial is right for you.